Remepy’s Digital molecules are mobile applications designed for hybrid drug experiences, each containing a unique digital treatment protocol. Our Digital molecules include digitized, standardized, evidence-based interventions, designed to enhance brain plasticity and connectivity, balance the immune system, and drive behavioral changes. We address disease end-points as well as side-effects and disease comorbidities
Digital Mechanisms of Action
Our interventions trigger unique mechanisms of action demonstrated in our clinical trials using fMRI imaging, blood and saliva samples, and standardized questionnaires. We directly impact brain activity and structure and have a downstream effect on the neuro-endocrine and neuro-immunological systems. Mechanisms of action amplify each other’s effect, creating a larger impact when activated together.
Enhance brain plasticity
Contrary to common belief, our brain maintains its plasticity in adulthood. Enriched multisensory environments can optimize neural structure and function, improve memory, motor, emotional and cognitive functioning.
Reduce systemic inflammation
Chronic stress causes neuroendocrine imbalance, activating the Sympathetic Nervous System and Hypothalamic-Pituitary-Adrenal axis, negatively impacting the immune system. This has a reciprocal influence on the brain - with systemic neuroinflammation accelerating brain neurodegeneration. Psychological and cognitive interventions target these mechanisms by positively impacting immune system function.
Trigger the reward system
Activation of the brain reward system has robust effects both on brain plasticity and on the immune system. A carefully designed interactive environment for cognitive training harnesses this ability by triggering activation in the brain reward system, in tandem with multi-modal beneficial behaviors reinforces the brain circuits involved in this behavior and sets off a beneficial cascade of neuro-immune effects.
Improve motor control
For diseases with movement disorders like Parkinson’s Disease, targeted physiotherapy interventions are added to the treatment protocol. These interventions are aimed at strengthening muscle memory to help with everyday tasks. For example: speech therapy, gross and fine motor skills, walking, and occupational therapy.
Rebalance emotion & cognitive networks
Evidence-based digital interventions addressing psychological symptoms, such as stress, anxiety, depression, and sleep are part of the treatment protocol. Interventions such as attention training, psychoeducation, thought and interpretation modification, and emotion regulation.
Non-invasive visual, auditory and tactile stimulation
We develop evidence based non-invasive cognitive, psychological, and behavioral interventions that follow principles of sensory integration, sensory substitution and sensory masking. Digital interventions are designed to trigger multiple mechanisms of action at play, enabling the synergistic effect. They aim to enhance (and sometimes prolong) the effect of the drug and address symptoms.
Spatial navigation
Motor control
Sensorimotor control
Memory control
Emotion regulation
Vestibular control
Publications
Activation of human visual area V6 during egocentric navigation with and without visual experience.
Current Biology, 2023
The effect of mindfulness-based interventions on immunity-related biomarkers: a comprehensive meta-analysis of randomised controlled trials.
Clinical psychology review, 2022
Multisensory processes: a balancing act across the lifespan.
Trends in neurosciences, 2016
Reading with sounds: sensory substitution selectively activates the visual word form area in the blind.
Neuron, 2012
Are critical periods reversible in the adult brain? Insights on cortical specializations based on sensory deprivation studies.
Neuroscience & Biobehavioral Reviews, 2020
Psychosocial interventions and immune system function: a systematic review and meta-analysis of randomized clinical trials.
AMA psychiatry, 2020
Stress management interventions to facilitate psychological and physiological adaptation and optimal health outcomes in cancer patients and survivors.
Annual review of psychology, 2023
We target drugs for diseases where meaningful changes to brain connectivity, changes to the immune system, and behavioral changes are synergistic with drug effects. Current focus areas include:
